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Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses.

Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses.
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Oliveira AF, Teixeira RR, Oliveira AS, Souza AP, Silva ML, Paula SO,


Oliveira AF, Teixeira RR, Oliveira AS, Souza AP, Silva ML, Paula SO, (click to view)

Oliveira AF, Teixeira RR, Oliveira AS, Souza AP, Silva ML, Paula SO,

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Molecules (Basel, Switzerland) 2017 03 2222(3) pii E505
Abstract

Dengue virus (DENV) and chikungunya virus (CHIKV) are reemergent arboviruses that are transmitted by mosquitoes of the Aedes genus. During the last several decades, these viruses have been responsible for millions of cases of infection and thousands of deaths worldwide. Therefore, several investigations were conducted over the past few years to find antiviral compounds for the treatment of DENV and CHIKV infections. One attractive strategy is the screening of compounds that target enzymes involved in the replication of both DENV and CHIKV. In this review, we describe advances in the evaluation of natural products targeting the enzymes involved in the replication of these viruses.

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