Immunology 2017 07 14() doi 10.1111/imm.12794
Macaca leonina (northern pig-tailed macaques, NPMs) have variable disease progression during SIVmac239 infection. In the present study, we analyzed, for the first time, the correlations between T cell phenotypes and disease progression in NPMs during SIVmac239 infection. In comparison to normal progressors (NPs), slow progressors (SPs) had lower chronic T cell activation and exhaustion levels. In addition, SPs showed higher peripheral CD4+ T cell count, CD4/CD8 ratio and lower plasma viral load than NPs. CD4+ T cell count and CD4/CD8 ratio decreased more sharply in NPs than in SPs. Furthermore, T cells in NPs were higher differentiated, at least in acute infection, than in SPs. These results indicated that T cell phenotypes were correlated with disease progression in SIVmac239-infected NPMs and these correlations may provide valuable guidance for the improvement of therapeutic strategies tested in NPMs. This article is protected by copyright. All rights reserved.