: Cost utility analysis is increasingly used by decision makers in patient management with chronic disease. Generic preference-based measures are used to evaluate disability and health-related quality of life (HRQoL).: To evaluate if Short Form Six Dimensions (SF-6Dv2) is correlated with specific current questionnaires used in chronic low back pain (CLBP) and if a predictive equation of SF-6Dv2 could be established.: Between October 2018 and January 2019, an online survey on CLBP was conducted. HRQoL was measured with two specific questionnaires, i.e. Oswestry Disability Index (ODI) and Roland-Morris Disability Questionnaire (RMDQ), and with the new version of the SF-6Dv2 as a generic preference-based measure.: 402 subjects completed at least two of the three HRQoL questionnaires. Mean (95% confidence interval) of SF-6Dv2, ODI or RMDQ were respectively 0.561 (0.553-0.569), 43.7 (42.1-45.2) and 10.3 (9.8-10.8). SF-6Dv2 was moderately correlated with ODI and RMDQ (r=-0.635 and r=-0.542, p<0.001). The best model to predict SF-6Dv2 explained 50.6% of variability and included ODI. The correlation between actual and predicted SF-6Dv2 was 0.71. Principal predictors were ODI, age and life satisfaction (0-10 cm).: This study demonstrated that SF-6Dv2 was moderately correlated with ODI and RMDQ and that ODI was a better predictor. There was a strong correlation between actual and predicted SF-6Dv2 from multivariate models. These results suggest that the model can be used in similar studies to estimate the SF-6Dv2 when it was not measured.