Many countries’ national immunization schedules recommend HPV vaccination for females until the age of 26, so a significant number of people of reproductive age may be exposed to HPV vaccines. The goal of this study was to see if inadvertent HPV vaccine exposure during the periconceptional period or during pregnancy was associated with an increased risk of adverse pregnancy outcomes. Studies that assessed the risk of adverse pregnancy outcomes in HPV vaccine exposed/unexposed pregnancies were included in the study. Spontaneous abortion, stillbirth, small for gestational age, preterm birth, and birth defects were among the negative pregnancy outcomes. Data gathering and analysis: The pooled relative risk (RR) was used as the study’s effect measure. When the effect was not reported in the paper, the RRs and 95% confidence intervals were calculated. The Cochrane Q and I2 statistics were used to assess study heterogeneity. The main findings are as follows: Eight of the 374 identified citations met the inclusion criteria. Pregnancies exposed to the HPV vaccine had no increased risk of spontaneous abortion, stillbirth, small for gestational age, preterm birth, or birth defects when compared to unexposed pregnancies.

Inadvertent bivalent/quadrivalent HPV vaccination during pregnancy was not linked to a significantly higher risk of adverse pregnancy outcomes.