To critically analyze and summarize studies connecting prenatal exposures with the start of childhood wheezing diseases published between July 2015 and June 2016, as well as to explore future research objectives in this subject was the purpose of this study. The data suggests that prenatal exposure to parental smoking, outdoor air pollution, and mother stress has a consistent negative influence on children wheezing diseases. Less consistent data shows that mother obesity during pregnancy and prenatal antibiotic exposure have a negative influence on these outcomes. There is inadequate evidence to establish a link between prenatal acetaminophen exposure or prenatal amounts of particular nutrients and childhood respiratory diseases.

A number of common possibly modifiable prenatal exposures appear to be consistently linked to childhood wheezing disorders. The influence of many additional prenatal exposures on the start of childhood wheezing diseases, on the other hand, is unknown. The available scientific data from the previous year does not permit us to offer any new recommendations on primary preventive strategies. Intervention studies will best illustrate if altering the prenatal environment can reduce wheezing disorders and asthma in children.