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Prevalence and Distribution of Coronary Artery Calcification in Asymptomatic United States and Korean Adults - Cross-Sectional Propensity-Matched Analysis.

Prevalence and Distribution of Coronary Artery Calcification in Asymptomatic United States and Korean Adults - Cross-Sectional Propensity-Matched Analysis.
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Han D, Ó Hartaigh B, Gransar H, Lee JH, Choi SY, Chun EJ, Sung J, Han HW, Park SH, Callister T, Lin FY, Min JK, Chang HJ,


Han D, Ó Hartaigh B, Gransar H, Lee JH, Choi SY, Chun EJ, Sung J, Han HW, Park SH, Callister T, Lin FY, Min JK, Chang HJ, (click to view)

Han D, Ó Hartaigh B, Gransar H, Lee JH, Choi SY, Chun EJ, Sung J, Han HW, Park SH, Callister T, Lin FY, Min JK, Chang HJ,

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Circulation journal : official journal of the Japanese Circulation Society 2016 Sep 2180(11) 2349-2355
Abstract
BACKGROUND
The incidence of coronary artery disease (CAD) varies depending on ethnicity, but the precise differences remain to be firmly established. This study therefore evaluated the disparity in coronary artery calcification (CAC), as a marker of CAD, in asymptomatic US and Korean adults.Methods and Results:CAC score was compared between asymptomatic Korean (n=15,128) and US (n=7,533) adults. Propensity score matching was performed according to age, gender, hypertension, diabetes, dyslipidemia, and current smoking, which generated 2 cohorts of 5,427 matched pairs. Both cohorts were categorized according to age group: 45-54, 55-64, and 65-74 years. Overall, the prevalence of CAC score >0, >100, and >400 in Korean adults was lower than in US adults (P<0.001, all). According to increasing age groups, the likelihood of CAC was most often lower in Korean adults, especially in Korean women. The odds of having CAC >400 in Korean adults aged 65-74 years was 0.66 (95% CI: 0.48-0.91) overall, 0.78 (95% CI: 0.52-1.19) in men, and 0.50 (95% CI: 0.29-0.86) in women, compared with US counterparts.

CONCLUSIONS
Korean adults have a lower prevalence and severity of atherosclerotic burden as assessed on CAC, compared with US adults, but the disparity in CAC according to ethnicity may decline with older age. (Circ J 2016; 80: 2349-2355).

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