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Prevalence and risk factors of nonalcoholic fatty liver disease in breast cancer patients.

Prevalence and risk factors of nonalcoholic fatty liver disease in breast cancer patients.
Author Information (click to view)

Lee S, Jung Y, Bae Y, Yun SP, Kim S, Jo H, Seo HI,


Lee S, Jung Y, Bae Y, Yun SP, Kim S, Jo H, Seo HI, (click to view)

Lee S, Jung Y, Bae Y, Yun SP, Kim S, Jo H, Seo HI,

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Tumori 2016 08 24103(2) 187-192 doi 10.5301/tj.5000536
Abstract
AIMS AND BACKGROUND
We aimed to evaluate the prevalence of nonalcoholic fatty liver disease (NAFLD) in breast cancer patients using liver magnetic resonance imaging (MRI), and to investigate factors associated with NAFLD.

METHODS
We evaluated 104 patients surgically treated for breast cancer at our hospital between September and November 2013. None of the patients had any other causes of secondary hepatic fat accumulation (such as significant alcohol consumption, use of steatogenic medication or inborn disorders). Hepatic fat accumulation was measured using liver MRI perfomed in all patients before surgical treatment.

RESULTS
Based on the fat signal percentage from liver MRIs, 19 of 104 breast cancer patients were diagnosed with NAFLD, so the prevalence of NAFLD was 18.3%. In univariate analysis, factors associated with NAFLD were older age, high body mass index, type 2 diabetes mellitus (DM), hypertension, elevated aspartate aminotransferase, elevated alanine aminotransferase and elevated triglycerides (TG). In multivariate analysis, factors associated with NAFLD were high body mass index (BMI) (odds ratio [OR] 1.403; 95% confidence interval [CI] 1.111-1.771; p = 0.005), type 2 DM (OR 11.872; 95% CI 1.065-132.373; p = 0.044), and an elevated TG level (OR 50.267; 95% CI 4.409-573.030; p = 0.002).

CONCLUSIONS
The prevalence of NAFLD in breast cancer patients was not different from that of the general population. High BMI, type 2 DM and an elevated serum TG level were factors associated with NAFLD.

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