In 2010, a national program, that involved 12 to 18 year old girls, for human papillomavirus (HPV) vaccination, was implemented by Bhutan.

The objective of this study is to examine the efficiency of the HPV vaccine in a particular city in Bhutan. In 2011-12 and in 2018, two cross sectional surveys were conducted involving 1445 women that were sexually active and were between 17 to 29 years of age.Vaccine and Non vaccine types were the two factions HPV was classified into and further in cervical cell samples HPV was assessed with the help of general primer GP5+/GP6+ -an arbitrator polymerase chain reaction. HVP was classified as HVP6/11/16/18 (vaccine types) and non vaccine types.

The Bill & Melinda Gates foundation provided the funds.

The overall and indirect adjusted VE against vaccine-targeted HPV types was 88% and 78%, respectively. The collective VE regulated amongst females who were below 27 years of age, and were aimed at by the vaccination program, was  93% and 88%, respectively.

The existence of vaccine oriented HPV types had reduced and that gave the very initial proof of the efficiency of a large scale national HPV program in a nation that has fairly low income i.e. Bhutan.