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Prevalence of Irritable Bowel Syndrome-like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease.

Prevalence of Irritable Bowel Syndrome-like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease.
Author Information (click to view)

Tomita T, Kato Y, Takimoto M, Yamasaki T, Kondo T, Kono T, Tozawa K, Yokoyama Y, Ikehara H, Ohda Y, Oshima T, Fukui H, Tanaka S, Shima M, Watari J, Miwa H,


Tomita T, Kato Y, Takimoto M, Yamasaki T, Kondo T, Kono T, Tozawa K, Yokoyama Y, Ikehara H, Ohda Y, Oshima T, Fukui H, Tanaka S, Shima M, Watari J, Miwa H, (click to view)

Tomita T, Kato Y, Takimoto M, Yamasaki T, Kondo T, Kono T, Tozawa K, Yokoyama Y, Ikehara H, Ohda Y, Oshima T, Fukui H, Tanaka S, Shima M, Watari J, Miwa H,

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Journal of neurogastroenterology and motility 22(4) 661-669 doi 10.5056/jnm15160
Abstract
Background/Aims
Few studies are available that have investigated the risk factors for overlapping irritable bowel syndrome (IBS)-like symptoms in patients with inactive inflammatory bowel disease (IBD). The present study has 3 objectives: (1) to assess the prevalence of IBS-like symptoms in Japanese patients with inactive IBD using Rome III criteria, (2) to examine the relationship of IBS-like symptoms to health related quality of life (HR-QOL), and (3) to investigate associations for developing IBS-like symptoms in patients with inactive IBD.

Methods
IBS-like symptoms were evaluated using the Rome III questionnaire for functional gastrointestinal disorders. HR-QOL and hospital anxiety and depression scale were evaluated.

Results
IBS-like symptoms were found in 17.5% (7/40) of patients with inactive ulcerative colitis, 27.1% (29/107) of patients with inactive Crohn’s disease (CD), and 5.3% (23/438) of healthy control subjects. The QOL level was significantly lower and anxiety score was significantly higher in inactive CD patients with IBS-like symptoms than in those without such symptoms (P = 0.003, P = 0.009). Use of anti-anxiety drugs was associated with the presence of IBS symptoms (P = 0.045). HR-QOL score was lower and anxiety score was higher in patients with inactive ulcerative colitis, but the difference was not statistically significant.

Conclusions
The prevalence of IBS-like symptoms in inactive IBD patients was significantly higher than in healthy controls. Inactive CD patients with IBS-like symptoms has low QOL and anxiety; suggesting that anxiety may be associated with symptom development in such patients.

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