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Prevalence of Sjögren’s syndrome in Brazilian patients infected with human T-cell lymphotropic virus.

Prevalence of Sjögren’s syndrome in Brazilian patients infected with human T-cell lymphotropic virus.
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Vale DA, Casseb J, de Oliveira AC, Bussoloti Filho I, de Sousa SC, Ortega KL,


Vale DA, Casseb J, de Oliveira AC, Bussoloti Filho I, de Sousa SC, Ortega KL, (click to view)

Vale DA, Casseb J, de Oliveira AC, Bussoloti Filho I, de Sousa SC, Ortega KL,

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Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2016 12 07() doi 10.1111/jop.12530

Abstract
BACKGROUND
Human T-lymphotropic virus type I (HTLV-I) is known to be associated with neoplastic and neurodegenerative changes, and it is believed to be associated with various systemic inflammatory diseases, including Sjögren’s syndrome (SS). Although HTLV-I infection is endemic in Brazil, there is no information regarding the association between HTLV-I infection and SS in the Brazilian population. The objective of this study was to determine the prevalence of SS in HTLV-I-infected individuals and the prevalence of HTLV-I-infection in individuals diagnosed with SS.

METHODS
Serology for HTLV-I was performed in 50 patients presenting with complaints consistent with SS (the SS group). The HTLV-I group comprised 129 HTLV-I-infected patients who were screened for SS.

RESULTS
None of the patients in the SS group tested positive for HTLV-I. Of the 129 patients in the HTLV-I group, 46 (35.7%) had xerostomia, 18 (13.95%) had xerophthalmia, 8 (6.2%) had hyposalivation, 2 (1.55%) showed impaired tear secretion, and 1 (0.77%) was positive for autoantibodies (anti-SSB). In addition, 6 underwent minor salivary gland biopsy, and the histopathological findings were consistent with SS. Only 2 (1.55%) met the diagnostic criteria for SS.

CONCLUSIONS
The prevalence of SS was found to be three times as high in HTLV-I-infected individuals as it was in those without HTLV-I infection. However, given the small number of HTLV-seropositive patients with SS, it is impossible to state that HTLV acts as an immune-activating pathogen for SS. This article is protected by copyright. All rights reserved.

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