Patients’ previous disability (PD) is a key factor when considering acute stroke therapy. PD’s exact impact on functional prognosis of patients with acute ischemic stroke remains not entirely clarified. We aimed to analyze PD’s influence on functional outcome three months after ischemic stroke.
Retrospective analysis of prospectively collected data concerning patients with acute ischemic stroke admitted to Stroke Unit of a tertiary center who underwent acute phase therapy between 2017 and 2019. Modified Rankin Scale (mRS) was used to define PD (with previous mRS≥3). Patients with PD were selected for treatment based on similar baseline characteristics to patients without PD. Patients were classified into two groups according to previous mRS: mRS<3 and mRS≥3. We defined bad outcome at three months after stroke as mRS≥3 for patients with previous mRS<3, and as a higher score than baseline mRS for patients with previous mRS≥3.
We identified 1169 eligible patients – 1016 patients with previous mRS<3 and 153 patients with previous mRS≥3. Most baseline characteristics did not differ significantly between them. For patients ≤75 years old, PD was associated with worse outcome (odds ratio estimate [OR] 4.50, p 75 years old, PD was protective against worse outcome (OR 0.42, p 75 years old, there was a higher proportion of women (p = 0.005).
PD might not be a relevant factor when considering acute stroke therapy in selected patients >75 years old, especially women. Further studies are needed to clarify these findings.

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