A reliable relationship between primary care doctors (PPs) and their patients is critical for vaccination uptake. Little is known regarding PPs’ opinions toward their patients’ involvement in a preventative vaccination trial (PVT) suggested by investigation sites. In the Auvergne-Rhône-Alpes area, a cross-sectional research was carried out, which included an anonymous questionnaire for general practitioners (GPs) and other specialists, as well as face-to-face interviews. A scenario was created in which a patient with chronic medical problems was encouraged to engage in a PVT and then reported the event to his or her PP. The attitudes of PPs were measured quantitatively using a 5-point Likert scale and qualitatively using semi-directed individual interviews. The questionnaire included 521 responses, 429 of whom were general practitioners and 92 of whom were other specialties. When presented with the situation, 312 respondents stated that they would respond spontaneously. Before expressing an opinion, PPs would like to learn more about the trial. 488’s attitude would be impacted by accessible safety facts, regardless of their stance. Face-to-face interviews revealed that PPs are unaware of clinical research and would prefer to learn more from investigators, particularly regarding safety.
PPs appear to be concerned about their patients’ decision to join or not engage in a PVT, although they would prefer more information regarding the study and clinical studies before forming an opinion. Increasing the involvement of PPs in the enrolment of patients in PVT may increase recruitment.