The Naples prognostic score (NPS) was associated with long-term survival among patients undergoing curative hepatectomy for hepatocellular carcinoma, according to findings published in the Journal of Hepatocellular Carcinoma. Lei Liang, PhD, and colleagues examined the impact of the NPS on long-term survival among 476 patients with HCC who underwent curative resection. Baseline characteristics indicated that patients with higher NPS had a greater proportion of poor liver function and advanced tumor features, and Kaplan-Meier survival curves demonstrated that patients with higher NPS had worse overall survival (OS) and recurrence-free survival (RFS). Multivariable analysis showed that NPS was an independent risk factor for OS (NPS group 2 vs 1: HR, 1.958; P=0.038; NPS group 3 vs 1: HR, 2.608; P=0.004) and RFS (NPS group 2 vs 1: HR, 2.014; P=0.002; NPS group 3 vs 1: HR, 2.002; P=0.003). NPS was superior to other models in prognostic performance and discriminatory power for long-term survival (P<0.05).