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Prognostic significance of the infiltration of CD163macrophages combined with CD66bneutrophils in gastric cancer.

Prognostic significance of the infiltration of CD163macrophages combined with CD66bneutrophils in gastric cancer.
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Huang X, Pan Y, Ma J, Kang Z, Xu X, Zhu Y, Chen J, Zhang W, Chang W, Zhu J,


Huang X, Pan Y, Ma J, Kang Z, Xu X, Zhu Y, Chen J, Zhang W, Chang W, Zhu J, (click to view)

Huang X, Pan Y, Ma J, Kang Z, Xu X, Zhu Y, Chen J, Zhang W, Chang W, Zhu J,

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Cancer medicine 2018 03 24() doi 10.1002/cam4.1420
Abstract

The polarization of tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs), especially from the antitumoral phenotype to the protumoral phenotype under certain conditions, has an important influence on the progression of tumors. However, the interactions and combined prognosis of these cells are poorly known. Here, we detected the infiltration of CD68TAMs, CD163TAMs, and CD66bTANs in the specimens from 662 patients with GC by immunohistochemistry. The results showed that the infiltration of each of CD163, CD68, and CD66bcells in GC tissue was significantly increased and independently associated with GC prognosis. Strong collinearity (r = 0.690, P < 0.001) was found between the infiltration of CD163and CD68cells in GC, and multivariate Cox analysis confirmed the infiltration of CD163cells was a better predictor for prognosis than that of CD68cells. The combination of the infiltration of CD163and CD66bcells provided more accurate survival prediction than any individual marker. Patient subgroups with CD66bCD163(hazard ratio (HR) = 2.161; 95% confidence interval (CI)  = 1.266-3.688; P < 0.001), CD66bCD163(HR = 3.575; 95% CI = 2.155-5.933; P < 0.001), and CD66bCD163(HR = 7.514; 95% CI = 4.583-12.312; P < 0.001) were gradually associated with shorter DFS when compared with the subgroup with CD66bCD163. The similar result was also for DSS among the subgroups. Moreover, the two-marker model could more effectively discriminate the prognosis among the patients with chemotherapy than that among those without chemotherapy. We concluded that CD163TAMs were a more valuable prognostic marker than CD68TAMs, and CD163TAMs combined with CD66bTANs could more precisely predict the prognosis of patients with GC.

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