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Prognostic value of nutritional risk screening 2002 scale in nasopharyngeal carcinoma: A large-scale cohort study.

Prognostic value of nutritional risk screening 2002 scale in nasopharyngeal carcinoma: A large-scale cohort study.
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Peng H, Chen BB, Tang LL, Chen L, Li WF, Zhang Y, Mao YP, Sun Y, Liu LZ, Tian L, Guo Y, Ma J,


Peng H, Chen BB, Tang LL, Chen L, Li WF, Zhang Y, Mao YP, Sun Y, Liu LZ, Tian L, Guo Y, Ma J, (click to view)

Peng H, Chen BB, Tang LL, Chen L, Li WF, Zhang Y, Mao YP, Sun Y, Liu LZ, Tian L, Guo Y, Ma J,

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Cancer science 2018 04 06() doi 10.1111/cas.13603

Abstract

Little is known about the value of the nutritional risk screening 2002 (NRS2002) scale in nasopharyngeal carcinoma (NPC). We conducted a large-scale study to address this issue. We employed a big-data intelligence database platform at our center and identified 3232 eligible patients treated between 2009 and 2013. Of the 3232 (12.9% of 24,986) eligible patients, 469 (14.5%), 13 (0.4%), 953 (29.5%), 1762 (54.5%), and 35 (1.1%) had NRS2002 scores of 1, 2, 3, 4, and 5, respectively. Survival outcomes were comparable between patients with NRS2002 < and ≥ 3 (original scale). However, patients with NRS2002 ≤ vs. >3 (regrouping scale) had significantly different 5-year disease-free survival (DFS; 82.7% vs. 75.0%, P < 0.001), overall survival (OS; 88.8% vs. 84.1%, P = 0.001), distant metastasis-free survival (DMFS; 90.2% vs. 85.9%, P = 0.001) and locoregional relapse-free survival (LRRFS; 91.6% vs. 87.2%, P = 0.001). Therefore, we proposed a revised NRS2002 scale, and found that it provides the best risk stratification than the original or regrouping scales for predicting DFS (area under the curve [AUC] = 0.530 vs. 0.554 vs. 0.577; P < 0.05), OS (AUC = 0.534 vs. 0.563 vs. 0.582; P < 0.05), DMFS (AUC = 0.531 vs. 0.567 vs. 0.590; P < 0.05) and LRRFS (AUC = 0.529 vs. 0.542 vs. 0.564; P < 0.05 except scale A vs. B). Our proposed NRS2002 scale represents a simple, clinically useful tool for nutritional risk screening in NPC. This article is protected by copyright. All rights reserved.

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