The main aim of this study is to review the effect of progranulin insufficiency on extracellular vesicles (EV) also with incongruous population of vesicles that may contribute towards progressive impact of neurodegenerative disease. It has been observed that loss of function mutations in progranulin (GRN) are a major cause of frontotemporal defemtia(FTD) , brains from GRN carriers with FTD (FTD-GRN) and these exhibits signs of lysosomal dysfunction. It has been observed that protein level contents of brain EVs from GRN mice , and that models lysosomal abnormalities of FTD-GRN patients. Thereafter measuremnts of brain EVs in FTD-GRN in patients are viewed. To analyse the relationship between EVs and syptomatic disease, plasma EVs are taken in consideration.  The results showed that any changes occurring were age dependent and emerged of pathology in GRN mice. FTD-GRN patients (n=13) had elevated brain EV levels related to controls (n=5). Then Symptomatic (n=12), but not presymptomatic (n=7), GRN carriers had also elevated plasma EV levels also relative to controls (n=8). Therefore we conclude that these data Show that symptomatic FTD-GRN patients have elevated levels of brain and plasma EVs, and this effect is moderate in the brain of GRN mice after the pathology testing.

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