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Progressive cutaneous Cryptococcosis complicated with meningitis in a myasthenia gravis patient on long-term immunosuppressive therapy – a case report.

Progressive cutaneous Cryptococcosis complicated with meningitis in a myasthenia gravis patient on long-term immunosuppressive therapy – a case report.
Author Information (click to view)

Huong NTC, Altibi AMA, Hoa NM, Tuan LA, Salman S, Morsy S, Lien NTB, Truong NT, Mai NTH, Hoa PTL, Thang NB, Trung VT,


Huong NTC, Altibi AMA, Hoa NM, Tuan LA, Salman S, Morsy S, Lien NTB, Truong NT, Mai NTH, Hoa PTL, Thang NB, Trung VT, (click to view)

Huong NTC, Altibi AMA, Hoa NM, Tuan LA, Salman S, Morsy S, Lien NTB, Truong NT, Mai NTH, Hoa PTL, Thang NB, Trung VT,

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BMC infectious diseases 2017 04 2617(1) 311 doi 10.1186/s12879-017-2415-8

Abstract
BACKGROUND
Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans and most remarkably manifests in HIV-infected individuals, especially in the settings of very low CD4 count. Development of cryptococcosis in HIV-uninfected individuals is exceedingly rare and usually signifies a marked immunodeficiency. Cryptococcosis in association with myasthenia gravis or thymoma has been previously documented in only very few cases in the literature.

CASE PRESENTATION
We reported a complicated case of severe cutaneous cryptococcosis in a 39-year-old Vietnamese male patient with myasthenia gravis on long-term immunosuppressive therapy. The patient presented with a five month history of recurrent and progressive skin lesions that later on progressed into cryptococcal meningitis.

CONCLUSION
Through this case, we aimed to emphasize the importance of including cutaneous cryptococcosis in the differential diagnosis of cutaneous lesions in patients on chronic immunosuppressive therapy. The cutaneous manifestations of cryptococcosis can be the first clue for a disseminated disease, which makes early recognition crucial and life-saving.

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