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Protein S-sulfhydration by hydrogen sulfide in cardiovascular system.

Protein S-sulfhydration by hydrogen sulfide in cardiovascular system.
Author Information (click to view)

Meng G, Zhao S, Xie L, Han Y, Ji Y,


Meng G, Zhao S, Xie L, Han Y, Ji Y, (click to view)

Meng G, Zhao S, Xie L, Han Y, Ji Y,

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British journal of pharmacology 2017 04 22() doi 10.1111/bph.13825
Abstract

Hydrogen sulfide (H2 S), independent on any specific transporters, plays a number of biological effects on cardiovascular systems. However, the detailed mechanism of H2 S is not yet clear until now. Recently, a novel post-translational modification induced by H2 S, named S-sulfhydration, has been proposed. S-sulfhydration is a chemical modification on specific cysteine residues of target proteins by H2 S. There are several methods for S-sulfhydration detection, such as modified biotin switch assay, maleimide assay with fluorescent thiol modifying regents, tag-switch method and mass spectrometry. H2 S induces S-sulfhydration on enzymes or receptors (such as p66Shc, phospholamban, protein tyrosine phosphatase 1B, mitogen-activated extracellular signal-regulated kinase 1, ATP synthase subunit α, etc.), transcription factors (such as specific protein-1, kelch-like ECH-associating protein 1, nuclear factor-κB and interferon regulatory factor-1, etc.), and ion channels (such as voltage-activated Ca(2+) channels, transient receptor potential channels, ATP-sensitive K(+) channels, etc.) in cardiovascular system. Although significant progress has been achieved in delineating the role of protein S-sulfhydration by H2 S in cardiovascular system, more proteins with detailed cysteine sites of S-sulfhydration as well as physiological function are to be investigated in further study. This review mainly summarizes the role and possible mechanism of S-sulfhydration in cardiovascular system. The S-sulfhydrated proteins propose novel targets for therapeutic intervention and drug design in cardiovascular system, which may accelerate the development and application of H2 S related drugs in the future.

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