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1.) Current estimates that the U.S. spends more than $155.7 billion annually for treatment of schizophrenia – including $117.3 billion in indirect costs such as lost wages. A study reported at Psych Congress looked at the economics of treating schizophrenia in an integrated healthcare system. Which of the following statements reflects a conclusion of that study?
a. Patients with schizophrenia consume a substantial amount of healthcare services.
b. Patients with schizophrenia have a number of inpatient visits for medical comorbidites.
c. There is a low rate of outpatient follow-up after inpatient visits or ED visits for schizophrenia.
d. All of the above.
2.) Olanzapine is well-recognized as an effective atypical antipsychotic for treatment of schizophrenia, but weight gain is a significant barrier to adherence. In clinical trials an investigational agent, ALKS 3831, which combines olanzapine with samidorphan, the olanzapine weight gain plateaued after week 8.
3.) A phase III study of a transdermal formulation of asenipine, a second-generation antipsychotic, demonstrated efficacy compared to placebo at what dose?
a. It was effective only at high dose, which was equivalent to 10 mg bid asenapine sublingual.
b. It was effective only at low dose, which was equivalent to 5 mg bid asenapine sublingual.
c. It was effective at both doses.
4.) An online survey of schizophrenia patients found that a majority of responders (92%) believed that antipsychotic medications worked, but just over half (51%0 said they thought the drugs did more harm than good.
5.) A cohort analysis of patients treated with Aristada initiated with a single oral loading dose of aripiprazole (30 mg), found that it was as effective as results seen in a cohort of patients treated with paliperidone palmitate. When compared to a cohort of patients initiated with 21 days of aripiprazole, the researchers reported that
a. It was superior to the 21-day initiation.
b. It was as effective as the 21-day initiation.
c. It was inferior to the 21-day initiation.
6.) Forensic psychiatrist Philip Resnick, MD, is regularly asked to consult on school shootings and mass shootings. Based on that work, he explained that school shooters are planners—they don’t act on impulse. Who is most likely to be aware of these plans?
7.) Schizophrenia patients often use multiple drugs. Based on an analysis of insurance claims –private claims and Medicare claims—what is the average time that it takes for an adult with schizophrenia to move from monotherapy to polypharmacy?
a. 4 Months
b. 6 months
c. 8 months
d. 2 months
8.) In the CATIE trial, a landmark study that established the efficacy of olanzapine for treatment of schizophrenia, what percent of patients had diabetes at baseline?
9.) An important consideration when selecting atypical antipsychotic medications is the number needed to treat (NNT) and the number needed to harm (NNH). An NNT of less than 10 suggests potential benefit for the drug. When considering NNH what threshold number indicates the drug is “desirable”?
a. More than 10
b. More than 20
c. Less than 10
d. Less than 20
10.) A study of a federally funded Assisted Outpatient Treatment Program in a rural Alabama county found that the in the first year of implementation, the program saved the county:
a. More than $1-million
b. More than $1.5-million