Cystic fibrosis (CF) is the most common autosomal recessive disease in the Caucasian population. Due to its pathological mechanism, chronic rhinosinusitis (CRS) associated or not with nasal polyposis usually occurs in adults and affects close to one-half of all CF patients. The researchers conducted this study to evaluate the impact of endoscopic sinus surgery (ESS) in the quality of life (QoL) of CF patients and demonstrate improved functional outcomes in the patients undergoing the surgical procedure than in the not treated ones.

The researchers studied 54 adult patients affected by CF. Lund–Kennedy, Lund–Mackay scores, and Sino-Nasal Outcome Test-22 (SNOT-22) were analyzed.

Twenty-two (40.7%) of the 54 CF patients underwent ESS. This group presented more likely complaints consistent with CRS. Lund–Kennedy and Lund–Mackay scores appeared higher in the ESS group: 10 (range of 6–12) and 16 (range of 12–20), respectively. SNOT-22 showed median values for the non-ESS and ESS group of 17.5 and 44 (range of 10–73), respectively.

The study concluded that ESS represents the best option to improve the clinical QoL of CF patients who do not respond to conventional medical therapy.