MR-guided focused ultrasound (MRgFUS) has been developed to treat essential tremor effectively and noninvasively. Currently, clinical examination is used to identify therapeutic efficacy during treatment, but MRgFUS surgery could benefit from real-time, rater-independent quantitative monitoring of tremor, such as accelerometry data.
Fourteen patients with medically refractory essential tremor underwent MRgFUS thalamotomy. Patients were instructed to hold postures during treatment. Tremor was monitored during each ultrasonic thermal sonication with MR-compatible accelerometers. Real-time feedback based on tremor amplitude in the 2-20 Hz band was calculated to evaluate the efficacy of each thermal ablation.
On average 6 ± 2 ablative sonications only were required to induce improvement in tremor on the clinical rating scale for tremor (CRST) of 89 ± 11% at + 7, 79 ± 12% at + 1, 74 ± 19% at + 3 and 72 ± 23% at + 12. The overall predictive efficacy measured with accelerometry during the treatment was 70 ± 30%. The tremor amplitude reduction measured with accelerometry was correlated with CRST scores tremor reduction at multiple timepoints ( = 0.79 at + 7, = 0.75 at + 1, = 0.86 at + 3, and = 0.63 at + 12) and accelerometric data gathered during treatment predicted CRST tremor improvement at + 3 (0.88 area under ROC curve).
This exploratory study is a proof of concept suggesting that accelerometry measurements can provide real-time feedback on tremor reduction and can complement visual evaluation. In the future, the use of the outcome prediction introduced in this paper may shorten procedure time and limit adverse events by reducing the number of ablative administered sonications.
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