This study states that We previously demonstrated that racial disparities exist in limb salvage outcomes in patients with peripheral artery disease (PAD), with blacks noted to have a twofold higher risk for major amputation than whites. We sought to evaluate the accuracy of the Wound, Ischemia, and foot Infection (WIfI) score in predicting amputation risk among racial groups. To better understand modifiable factors associated with poorer outcomes in the black population, we sought to investigate whether the WIfI score at initial presentation with chronic limb-threatening ischemia (CLTI) varied among racial groups. A single-center academic institution’s electronic medical record database was queried to identify all patients presenting with an initial diagnosis of CLTI from 2007 to 2018. Data were collected on race, age, sex, socioeconomic status, medical comorbidities, and outcomes including major amputation and mortality. Chart review gathered information on wound characteristics, ischemia severity, and extent of infection to calculate the WIfI score at initial presentation. A logistic regression model was used to analyze the association between WIfI score, amputation risk, and race while controlling for comorbidities.