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Radiofrequency ablation of primary thyroid carcinoma: efficacy according to the types of thyroid carcinoma.

Radiofrequency ablation of primary thyroid carcinoma: efficacy according to the types of thyroid carcinoma.
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Jeong SY, Baek JH, Choi YJ, Chung SR, Sung TY, Kim WG, Kim TY, Lee JH,


Jeong SY, Baek JH, Choi YJ, Chung SR, Sung TY, Kim WG, Kim TY, Lee JH, (click to view)

Jeong SY, Baek JH, Choi YJ, Chung SR, Sung TY, Kim WG, Kim TY, Lee JH,

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International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2018 01 24() 1-6 doi 10.1080/02656736.2018.1427288

Abstract
OBJECTIVE
To evaluate the efficacy of ultrasound (US)-guided radiofrequency ablation (RFA) according to the types of thyroid carcinoma, particularly in patients with a high-surgical risk.

MATERIALS AND METHODS
Eight patients with nine tumours of pathologically proven papillary and anaplastic carcinoma were treated by US-guided RFA. Patients with primary thyroid carcinoma were divided into three groups; group (1) Anaplastic carcinoma, group (2) papillary macrocarcinoma, and group (3) papillary microcarcinoma. We evaluated changes in clinical symptoms, tumour volume and local tumour recurrence/metastasis after RFA. Patients were followed up at 1, 6 and 12 months and annually thereafter.

RESULTS
Among nine tumours, one anaplastic carcinoma was treated three times and the other anaplastic carcinoma and one papillary macrocarcinoma were treated twice. Group 3 were treated once. The initial mean tumour volume was 107.9 ± 78.6 (with neck bulging), 126.9 (with neck bulging) and 0.16 ± 0.08 mL (without cosmetic or symptomatic problems) in groups 1-3, respectively. Group 1 showed no improvement in clinical symptoms or neck bulging after RFA, whereas group 2 demonstrated a decreased tumour volume measuring 0.7 mL with improved neck bulging. In group 3, mean volume decreased measuring 0.07 ± 0.12 mL. No local tumour recurrence or metastatic lesion was detected during the mean follow-up of 19.3 months in papillary carcinomas. No major complications were encountered.

CONCLUSIONS
In patients with primary thyroid carcinoma, RFA achieved excellent local tumour control for papillary macro- and microcarcinoma; however, its clinical effect on anaplastic carcinoma was questionable.

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