For a study, it was determined that the tremendous rise in food allergies emphasized the need for more definite treatment options that created long-term oral tolerance, as well as more effective primary preventive measures. Allergen-induced oral tolerance was becoming a hot topic in each of these situations, as a possibly more successful alternative to standard avoidance techniques. Researchers looked at recent randomized controlled trials (RCTs) that examined controlled allergen exposure in both the treatment and prevention of food allergies. RCTs of oral immunotherapy (OIT) for the treatment of food allergy, taken together, enhanced the quantity of food allergen that could be tolerated. Allergic adverse effects were prevalent, and that continued to be a major barrier to widespread usage in clinical practice. In addition, at least eight randomized controlled trials (RCTs) were presently underway to investigate early allergen exposure for the main prevention of food allergy.

OIT was showing promise as a potential therapy for food allergies; however, further large, long-term trials were needed to maximize both safety and efficacy, as well as to analyze long-term consequences, before it could be considered in clinical practice. The main preventive studies’ findings were critical in evaluating the effect of earlier introduction of allergenic foods in lowering the burden of food allergy.