This study was done to provide a description of an interesting case of severe adult-onset difficult-to-treat atopic dermatitis dramatically improved in response to treatment with Omalizumab.
An adult male was observed with severe allergic atopic dermatitis, with concomitant involvement of the face, neckline, trunk, and forearm. There were also reported systemic symptoms such as diarrhea with an important decrease of his daily quality of life. The patient was using oral steroids in addition to anti-histamines to no avail. In this patient there was a lack of response to classic therapies, strict diet, as well as to treatment with intravenous corticosteroids, an off-label treatment with Omalizumab based on patient weight, and total IgE value was proposed. Results were observed after only a few weeks with regards to systemic symptoms, and just after 2 months of treatment in regards to skin involvement.
The study concluded through its findings that the outstanding rapid response was observed in this case as well as the persistence of the clinical remission that suggests that the block of the IgE pathways modulate functions of cells involved in the pathogenic mechanisms of chronic skin inflammation but also in the acute phases observed in the flare-ups of the disease.
Reference: https://clinicalmolecularallergy.biomedcentral.com/articles/10.1186/s12948-019-0109-z
