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Recent advances of pyrazole-containing derivatives as anti-tubercular agents.

Recent advances of pyrazole-containing derivatives as anti-tubercular agents.
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Xu Z, Gao C, Ren QC, Song XF, Feng LS, Lv ZS,


Xu Z, Gao C, Ren QC, Song XF, Feng LS, Lv ZS, (click to view)

Xu Z, Gao C, Ren QC, Song XF, Feng LS, Lv ZS,

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European journal of medicinal chemistry 2017 08 03139() 429-440 pii 10.1016/j.ejmech.2017.07.059

Abstract

One-third of the world’s population infected tuberculosis (TB), and more than 1 million deaths annually. The co-infection between the mainly pathogen Mycobacterium tuberculosis (MTB) and HIV, and the incidence of drug-resistant TB, multi-drug resistant TB, extensively drug-resistant TB as well as totally drug-resistant TB have further aggravated the mortality and spread of this disease. Thus, there is an urgent need to develop novel anti-TB agents against both drug-susceptible and drug-resistant TB. The wide spectrum of biological activities and successful utilization of pyrazole-containing drugs in clinic have inspired more and more attention towards this kind of heterocycles. Numerous of pyrazole-containing derivatives have been synthesized for searching new anti-TB agents, and some of them showed promising potency and may have novel mechanism of action. This review aims to outline the recent achievements in pyrazole-containing derivatives as anti-TB agents and their structure-activity relationship.

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