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Reduced trans-placental transfer of group B Streptococcus surface protein antibodies in HIV-infected mother-newborn dyads.

Reduced trans-placental transfer of group B Streptococcus surface protein antibodies in HIV-infected mother-newborn dyads.
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Dzanibe S, Adrian PV, Kimaro Mlacha SZ, Dangor Z, Kwatra G, Madhi SA,


Dzanibe S, Adrian PV, Kimaro Mlacha SZ, Dangor Z, Kwatra G, Madhi SA, (click to view)

Dzanibe S, Adrian PV, Kimaro Mlacha SZ, Dangor Z, Kwatra G, Madhi SA,

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The Journal of infectious diseases 2016 12 08() pii

Abstract

We evaluated the effect of maternal HIV infection on trans-placental antibody transfer specific to eight group B Streptococcus (GBS) surface protein among 81 HIV-uninfected and 83 HIV-infected mother-newborn pairs using a multiplex immunoassay. Significantly lower antibody titres were detected in HIV-infected mothers and HIV-exposed uninfected newborns compared to HIV-uninfected mother-newborn dyads. Maternal HIV infection was also associated with reduced trans-placental transfer of antibodies for Sip (25.8%), Foldase (30.4%), gba0392 (36.5%), gbs0393 (32.9%), gbs1539 (39.2%), gbs2106 (35.7%) and BibA (19.4%), p<0.003. This reduced trans-placental antibody transfer might contribute to increased susceptibility for invasive GBS disease in HIV-exposed uninfected infants.

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