Dzanibe S, Adrian PV, Kimaro Mlacha SZ, Dangor Z, Kwatra G, Madhi SA, (click to view)
The Journal of infectious diseases 2016 12 08() pii
Abstract
We evaluated the effect of maternal HIV infection on trans-placental antibody transfer specific to eight group B Streptococcus (GBS) surface protein among 81 HIV-uninfected and 83 HIV-infected mother-newborn pairs using a multiplex immunoassay. Significantly lower antibody titres were detected in HIV-infected mothers and HIV-exposed uninfected newborns compared to HIV-uninfected mother-newborn dyads. Maternal HIV infection was also associated with reduced trans-placental transfer of antibodies for Sip (25.8%), Foldase (30.4%), gba0392 (36.5%), gbs0393 (32.9%), gbs1539 (39.2%), gbs2106 (35.7%) and BibA (19.4%), p<0.003. This reduced trans-placental antibody transfer might contribute to increased susceptibility for invasive GBS disease in HIV-exposed uninfected infants.