Eosinophils, mast cells, basophils, and neutrophils are examples of inflammatory cells that produce sialoglycan-binding proteins like Siglec-8 and Siglec-9, which limit cell function and survival. The goal of this study is to provide a brief overview of the biology of these siglecs and their ligands, as well as their possible role in the pathogenesis and therapy of chronic rhinosinusitis (CRS). Recent research has shown ligands for Siglec-8 and Siglec-9 in sinus tissue from both CRS patients and healthy people, indicating that the immunoregulatory activities of siglecs may be activated in sinus tissue in both health and illness.
Ligands for Siglec-8 and Siglec-9 may influence eosinophils, mast cells, neutrophils, and other cells in the sinus mucosa. In CRS patients, therapeutic methods that stimulate siglecs’ anti-inflammatory actions may reduce inflammation and illness.
