Dendritic cells are important in inflammatory and tolerant reactions. With the pressure of allergic illnesses rising across the world, it is important to learn more about the processes behind those illnesses. This analysis highlights findings on how dendritic cells affect the development of allergic diseases and provide valuable mechanistic insight into existing clinical management strategies and possible fields in which new therapeutic strategies can be further developed. Recent experiments help to clarify mechanisms associated with dendritic cells, which may either support allergic inflammation or avoid it. Mechanisms involving dendritic cell function have different elements, from a sample of antigens to dendritic cell migration, to complex dendritic cell associations in other immune cells, infectious agents and allergens. A deeper analysis into these pathways and how dendritic cells facilitate toleration gives insights into possible methods for treatment of allergic disease by dendritic cells.

Recent research shows that dendritic cells play key roles as reactive vs. receptive cascades regulators. Building on oncological techniques to harness dendritic cells to facilitate antitumor responses, some novel mechanisms might also promote allergy-mediated dendritic cell tolerances. In these possible techniques for reducing allergic inflammation, more research is still needed to further identify the functions and possible consequences of dendritic cells.

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Reference: https://journals.lww.com/co-allergy/Abstract/2020/02000/Regulation_of_allergic_inflammation_by_dendritic.10.aspx