Relationship Between TyG-WHtR Index and Overactive Bladder Risk

Apr 22, 2025

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The following is a summary of “Association between triglyceride glucose-waist height ratio index and overactive bladder: based on NHANES 2005-2018,” published in the April 2025 issue of Frontiers in Endocrinology by Mao et al.

Researchers conducted a retrospective study to examine the association between the triglyceride glucose-waist height ratio (TyG-WHtR) index and the risk of developing an overactive bladder (OAB).

They employed data from the National Health and Nutrition Examination Survey (NHANES) and conducted a weighted multivariate logistic regression to assess the relationship between TyG-WHtR and OAB. Subgroup analyses and interaction tests were performed, and sensitivity analyses validated the findings. Nonlinear relationships between TyG-WHtR and OAB risk were explored using smooth curve fitting and threshold effect analysis. The predictive value of TyG-WHtR for OAB was estimated with Receiver Operating Characteristic (ROC) curves, and the area under the ROC curve (AUC) was calculated.

The results showed that 14,652 adults aged 20 and above were included, with an estimated weighted population size of 1,97,598,146.7, of whom 37,872,284.55 had OAB. The median TyG-WHtR was 4.98 for the entire population and 5.44 for those with OAB. Logistic regression revealed a positive association between TyG-WHtR and OAB occurrence (odds ratio (OR)=1.646; 95% CI: 1.562, 1.735; P<0.001), which remained significant after adjusting for confounders (OR=1.310; 95% CI: 1.157, 1.484; P<0.001). Sensitivity analysis confirmed the findings. Subgroup and interaction analyses showed that gender (OR=1.323; 95% CI: 1.138, 1.538; P<0.001) and age (OR=1.426; 95% CI: 1.180, 1.724; P<0.001) influenced the association. Smooth curve fitting and threshold effect analysis identified a threshold of 3.579 and ROC curve analysis indicated good predictive ability for OAB (AUC=0.647; 95% CI: 0.636, 0.657).

Investigators concluded that the TyG-WHtR index had been significantly positively associated with the occurrence of OAB and could potentially have served as a novel risk predictor for OAB.

Source: frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1541218/full