Advertisement

 

 

Renal clear cell carcinoma: diffusion tensor imaging diagnostic accuracy and correlations with clinical and histopathological factors.

Renal clear cell carcinoma: diffusion tensor imaging diagnostic accuracy and correlations with clinical and histopathological factors.
Author Information (click to view)

Feng Q, Fang W, Sun XP, Sun SH, Zhang RM, Ma ZJ,


Feng Q, Fang W, Sun XP, Sun SH, Zhang RM, Ma ZJ, (click to view)

Feng Q, Fang W, Sun XP, Sun SH, Zhang RM, Ma ZJ,

Advertisement

Clinical radiology 2017 03 1972(7) 560-564 pii S0009-9260(17)30081-8
Abstract
AIM
To investigate whether diffusion tensor imaging (DTI) can be used to assess renal clinical histopathology, including the nuclear grade (NG), cell density (CD), and the presence of ki-67.

MATERIALS AND METHODS
Thirty patients were enrolled in the study and were confirmed at surgical histopathology to have clear cell renal cell carcinoma (CCRCC). For DTI, a coronal echo-planar imaging sequence was performed (1400 ms repetition time, 76 ms echo time, diffusion direction=6, number of excitations=4; b=0 and 800 s/mm(2), 6 mm section thickness with no intersection gap). CD and the presence of ki-67 were compared between the different NGs. Correlations between apparent diffusion coefficients (ADCs), E1, fractional anisotropy (FA), CD, and ki-67 were evaluated.

RESULTS
ADC, E1, and FA values are important tools used to identify NG. The cut-off values were 1.003×10(-3) mm(2)/s, 1.277×10(-3) mm(2)/s, and 0.218 mm(2)/s, respectively. The difference between high- and low-grade CD was significant (t=-4.50, p<0.05). Similarly, a significant difference between high and low grade was also found in ki-67 (t=-4.03, p<0.05). ADC, E1, and FA values were decreased with increased CD; a significant negative correlation was found (r=-0.796, -0.865, and -0.996, respectively). Significant negative correlations between ADC, E1, and FA values, and ki-67 were found (r=-0.739, -0.826, and -0.876, respectively). CONCLUSIONS
DTI can be used to non-invasively assess CCRCC.

Submit a Comment

Your email address will not be published. Required fields are marked *

13 + 7 =

[ HIDE/SHOW ]