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The following is a summary of “Prevalence and factors linked to renal involvement in prediabetes patients across Europe in the ePREDICE trial,” published in the December 2024 issue of Nephrology by Mas-Fontao et al.
Researchers conducted a retrospective study in the Early Prevention of Diabetes Complications in People with Hyperglycemia (ePREDICE) trial to examine renal complications in patients with prediabetes (PD), identifying key factors such as glomerular hyperfiltration, albuminuria, and reduced kidney function.
They included 967 participants from 7 countries and evaluated kidney function using the MDRD-4 equation. Multivariable regression models assessed the impact of clinical and demographic factors on renal involvement, and insulinogenic and disposition indices were also examined.
The results showed that the cohort had renal abnormalities in 9.2% (n = 89). Hyperfiltration was found in 2% (n = 20), albuminuria in 4.7% (n = 45), and CKD stage G3a in 3% (n = 29). Hyperfiltration was inversely correlated with age and height, while albuminuria was directly associated with the disposition index (DI). Age and waist circumference were significantly linked to the estimated glomerular filtration rate (eGFR).
Investigators emphasized the need for early detection of kidney abnormalities in PD, especially in older individuals with larger waist circumferences.
Source: nature.com/articles/s41598-024-79842-w#Abs1
