Hepatology research : the official journal of the Japan Society of Hepatology 2017 07 08() doi 10.1111/hepr.12935
BACKGROUND & AIMS
Renal venous hypertension is known to be associated with worsening of renal function in patients with decompensated heart failure. Intra-abdominal hypertension including cirrhotic ascites also leads to renal venous hypertension. We aimed to clarify the effect of renal venous hypertension on cirrhotic ascites.
Two hepatologists measured the left renal vein diameter in 142 consecutive patients with refractory cirrhotic ascites using non-contrast computed tomography. The renal vein diameter was measured at the renal vein main trunk and upstream of the confluence of collateral veins.
The inter-observer agreements were high for the measurements of the left renal vein (r=0.918, P<0.001). The median overall survival (OS) for patients with renal vein diameter ≥11mm was less than that for patients with renal vein diameter < 11mm (P < 0.001; 2.5vs. 32.0 months). One-year survival rates were 15.3% vs 66.4%. Multivariate analysis revealed renal vein diameter ≥11mm (hazard ratio [HR]: 2.94; P < 0.001; 95% confidence interval [CI]: 1.67-5.20) and a high model for end-stage liver disease (MELD) Na score (HR: 3.39; P<0.001; 95% CI: 2.00-5.74) were significant independent predictors of mortality. CONCLUSIONS
Renal vein dilation is a risk factor of mortality in patients with refractory cirrhotic ascites, independent of the MELD-Na score.