Advertisement

 

 

Research: A comprehensive and quantitative exploration of thousands of viral genomes.

Research: A comprehensive and quantitative exploration of thousands of viral genomes.
Author Information (click to view)

Mahmoudabadi G, Phillips R,


Mahmoudabadi G, Phillips R, (click to view)

Mahmoudabadi G, Phillips R,

Advertisement

eLife 2018 04 067() doi 10.7554/eLife.31955
Abstract

The complete assembly of viral genomes from metagenomic datasets (short genomic sequences gathered from environmental samples) has proven to be challenging, so there still remain significant blind spots in our view of viral genomes through the lens of metagenomics. One approach to overcoming this problem is to leverage the thousands of complete viral genomes that are publicly available. Here we describe our efforts to assemble a comprehensive resource that provides a quantitative snapshot of viral genomic trends – such as gene density, noncoding percentage, and abundances of functional gene categories – across thousands of viral genomes. We have also developed a coarse-grained method for visualizing viral genome organization for hundreds of genomes at once, and have explored the extent of the overlap between bacterial and bacteriophage gene pools. Existing viral classification systems were developed prior to the sequencing era, so we present our analysis in a way that allows us to assess the utility of the different classification systems for capturing genomic trends.

Submit a Comment

Your email address will not be published. Required fields are marked *

1 + 6 =

[ HIDE/SHOW ]