The miRNA profile of nasal mucosal fluid from patients with NSAID-exacerbated respiratory disease (N-ERD), the hallmark of which is a severe course and the presence of chronic rhinosinusitis (CRS) with nasal polyps, varies from patients with allergic asthma (AA), CRS, and healthy controls, according to results published in Allergy, Asthma and Immunology Research. Marcin Kurowski, MD, PhD, and colleagues evaluated the miRNA profile of patients with N-ERD, CRS, and AA, plus controls. In total, 23 miRNAs differed between patients with N-ERD and controls. Based on that, the researchers selected six miRNAs for further validation in 77 patients. Patients with N-ERD had significantly different expression of miR-34a5p and miR-22-5p versus those with AA. Among all patients, correlations were seen between miR7d-3p/miR-34a-5p/miR-22-5p and the presence of blood eosinophilia (P<0.05). Forced expiratory volume in 1 second/forced vital capacity also correlated with miR-149a-5p expression (P<0.05). “Specific miRNAs may be considered as potential biomarkers of N-ERD,” the researchers wrote.