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Respiratory viral infections and atopic development: From possible mechanisms to advances in treatment.

Respiratory viral infections and atopic development: From possible mechanisms to advances in treatment.
Author Information (click to view)

Martorano LM, Grayson MH,


Martorano LM, Grayson MH, (click to view)

Martorano LM, Grayson MH,

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European journal of immunology 2017 12 15() doi 10.1002/eji.201747052
Abstract

Atopic sensitization and allergic diseases are increasing in modernized countries. These diseases affect millions of individuals, but the mechanisms behind their development are not fully understood. One hypothesis relates to early life respiratory viral infections driving the development of atopic disease including asthma. This review presents the current state of the field, focusing on epidemiologic data supporting a role for early life respiratory viruses in the development of specific IgE, both against aeroallergens and the respiratory virus. Our own work using the Sendai mouse model is then summarized to provide a potential mechanistic explanation for how a respiratory viral infection could drive development of atopic sensitization and disease. We then discuss the components of this mechanistic pathway that have and have not been validated in humans. Finally, we discuss areas ripe for research, as well as potential and current therapeutics that might disrupt the link between respiratory viral infections in early life and atopic sensitization/disease. This article is protected by copyright. All rights reserved.

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