Advertisement

 

 

Response to therapy of papillary thyroid cancer of known BRAF status.

Response to therapy of papillary thyroid cancer of known BRAF status.
Author Information (click to view)

Kowalska A, Walczyk A, Kowalik A, Pałyga I, Gąsior-Perczak D, Trybek T, Kopczyński J, Kajor M, Mikina E, Szymonek M, Gadawska-Juszczyk K, Szyska-Skrobot D, Lizis-Kolus K, Hurej S, Chrapek M, Chłopek M, Góźdź S,


Kowalska A, Walczyk A, Kowalik A, Pałyga I, Gąsior-Perczak D, Trybek T, Kopczyński J, Kajor M, Mikina E, Szymonek M, Gadawska-Juszczyk K, Szyska-Skrobot D, Lizis-Kolus K, Hurej S, Chrapek M, Chłopek M, Góźdź S, (click to view)

Kowalska A, Walczyk A, Kowalik A, Pałyga I, Gąsior-Perczak D, Trybek T, Kopczyński J, Kajor M, Mikina E, Szymonek M, Gadawska-Juszczyk K, Szyska-Skrobot D, Lizis-Kolus K, Hurej S, Chrapek M, Chłopek M, Góźdź S,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Clinical endocrinology 2017 08 0487(6) 815-824 doi 10.1111/cen.13423

Abstract
OBJECTIVE
A dynamic risk stratification with modified initial estimated risk based on response to therapy and disease course is one of the crucial changes adopted recently by the American Thyroid Association (ATA). This approach focuses on an individualized risk-adapted approach to the management of differentiated thyroid cancer. The BRAF V600E mutation is the most common genetic alteration in papillary thyroid cancer (PTC). However, the prognostic value of this mutation remains unclear. The aim of this study was to examine the relation between the BRAF V600E status in PTC and all ATA response-to-therapy categories, as well as the recurrence and persistence of both biochemical disease and structural disease.

PATIENTS
Unselected PTC cases with known BRAF status diagnosed from 2000 to 2013 and actively monitored at one institution (n=723) were reviewed retrospectively. The association between the BRAF V600E mutation and clinicopathological characteristics, ATA 2015 response-to-therapy category, recurrence after a period of no evidence of disease (NED) and persistent biochemical or structural disease, was analysed.

RESULTS
BRAF V600E was found in 65.7% (475/723) of PTC cases. Although BRAF mutation status correlated significantly with certain clinicopathological prognostic factors, there was no correlation with any of the response-to-therapy categories. Recurrences and persistent biochemical or structural disease were not associated with BRAF status.

CONCLUSIONS
Our data are consistent with those of other studies reporting a positive relation between BRAF V600E mutation and poor prognostic factors in PTC; however, the BRAF status did not significantly correlate with a response to therapy.

Submit a Comment

Your email address will not be published. Required fields are marked *

thirteen − six =

[ HIDE/SHOW ]