To describe a case of post-operative retinal toxicity following the use of mitomycin C during a routine trabeculectomy.
Case report of a single patient who underwent complete ophthalmic examination and multimodal imaging, including color fundus photos, optical coherence tomography (OCT), fundus autofluorescence (FAF), and fluorescein angiography (FA). The study was declared exempt by the Institutional Review Board of Northwestern University. This research followed the tenets of the Declaration of Helsinki.
The patient developed profound vision loss and retinal damage during the post-operative course. Posterior segment findings include loss of vascular perfusion, diffuse loss of the outer, then inner, retinal layers, and subsequent total retinal detachment.
While MMC is commonly used in glaucoma filtering surgeries, reports of post-operative posterior segment toxicity are rare. The etiology of post-operative toxicity in this case is probable inadvertent intraocular injection of MMC.

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