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Retroviral restriction: nature’s own solution.

Retroviral restriction: nature’s own solution.
Author Information (click to view)

Jones CE, McKnight Á,


Jones CE, McKnight Á, (click to view)

Jones CE, McKnight Á,

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Current opinion in infectious diseases 29(6) 609-614

Abstract
PURPOSE OF REVIEW
The present review will discuss recent advances in the development of anti-HIV therapies inspired by studies of the mechanisms of host restriction factor-mediated resistance to HIV infection.

RECENT FINDINGS
Manipulating the interplay between host cell restriction factors and viral accessory factors that overcome them can potentially be therapeutically useful. Preliminarily successful therapies – some of which are entering clinical trials – either inhibit the ability of virus to evade restriction factor-mediated immunity, or promote intracellular levels of restriction factors. These aims are achieved by multiple means, which are discussed.

SUMMARY
Many restriction factors appear to provide potentially useful targets for anti-HIV therapies, so time and interest should be invested in investigating ways to successfully therapeutically manipulate restriction factor-mediated immunity.

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