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Rhadinoviral interferon regulatory factor homologues.

Rhadinoviral interferon regulatory factor homologues.
Author Information (click to view)

Koch S, Schulz TF,


Koch S, Schulz TF, (click to view)

Koch S, Schulz TF,

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Biological chemistry 398(8) 857-870 doi 10.1515/hsz-2017-0111

Abstract

Kaposi’s sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8) is a gammaherpesvirus and the etiological agent of Kaposi’s sarcoma, primary effusion lymphoma and multicentric Castleman disease. The KSHV genome contains genes for a unique group of proteins with homology to cellular interferon regulatory factors, termed viral interferon regulatory factors (vIRFs). This review will give an overview over the oncogenic, antiapoptotic and immunomodulatory characteristics of KSHV and related vIRFs.

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