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Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR.

Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR.
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Liu F, Wang YN, Li Y, Ma SG, Qu J, Liu YB, Niu CS, Tang ZH, Zhang TT, Li YH, Li L, Yu SS,


Liu F, Wang YN, Li Y, Ma SG, Qu J, Liu YB, Niu CS, Tang ZH, Zhang TT, Li YH, Li L, Yu SS, (click to view)

Liu F, Wang YN, Li Y, Ma SG, Qu J, Liu YB, Niu CS, Tang ZH, Zhang TT, Li YH, Li L, Yu SS,

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Scientific reports 2017 08 117(1) 7944 doi 10.1038/s41598-017-06320-x
Abstract

Rhodoterpenoids A‒C (1‒3), three new rearranged triterpenoids, together with one new biogenetically related compound, rhodoterpenoid D (4), were isolated and efficiently elucidated from Rhododendron latoucheae by high-performance liquid chromatography-mass spectrometry-solid-phase extraction-nuclear magnetic resonance (HPLC‒MS‒SPE‒NMR). Compounds 1 and 2 possess an unprecedented skeleton with a 5/7/6/6/6-fused pentacyclic ring system, while compound 3 contains a unique 6/7/6/6/6-fused pentacyclic carbon backbone. Their structures were determined by extensive spectroscopic methods and electronic circular dichroism (ECD) analyses. Plausible biogenetic pathways for 1‒4 were proposed. Compounds 1 and 4 showed potential activity against herpes simplex virus 1 (HSV-1) with IC50 values of 8.62 and 6.87 μM, respectively.

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