Advertisement

 

 

Risk factors for incident asthma and COPD in a cohort of young adults.

Risk factors for incident asthma and COPD in a cohort of young adults.
Author Information (click to view)

Traulsen LK, Baelum J, Halling A, Thomsen G, Thilsing T, Sherson D, Sigsgaard T, Omland Ø, Malling T, Skadhauge LR,


Traulsen LK, Baelum J, Halling A, Thomsen G, Thilsing T, Sherson D, Sigsgaard T, Omland Ø, Malling T, Skadhauge LR, (click to view)

Traulsen LK, Baelum J, Halling A, Thomsen G, Thilsing T, Sherson D, Sigsgaard T, Omland Ø, Malling T, Skadhauge LR,

Advertisement

The clinical respiratory journal 2017 03 07() doi 10.1111/crj.12622
Abstract
INTRODUCTION
The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, nine-year follow-up study.

METHODS
From a cohort of 1,191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014.

RESULTS
A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1,000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV1 <100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV1 <100% predicted (all male cases had FEV1 <100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34). CONCLUSIONS
No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasise considerable gender differences. This article is protected by copyright. All rights reserved.

Submit a Comment

Your email address will not be published. Required fields are marked *

five × 5 =

[ HIDE/SHOW ]