The aim of this study is to understand the Claudication has a relatively benign natural history associated with a low risk of limb loss. Recent reports raise concerns about accelerated disease progression after lower extremity revascularization (LER). This study examined the long-term outcomes and risk factors associated with progression to chronic limb-threatening ischemia (CLTI) after LER for claudication. A single-center retrospective review of patients undergoing LER for claudication was performed from 2013 to 2016. Patients were stratified on the basis of whether they progressed to CLTI. Patients who developed CLTI had significantly higher rates of reinterventions after index LER before development of CLTI compared with those who did not progress. Patients who progressed to CLTI had significantly higher rates of major amputation and mortality. However, the overall major amputation rate of the total patient population was low (1.2%). Patients with symptomatic atherosclerosis in the coronary and cerebrovascular beds are more likely to have progression of claudication to CLTI after LER. Initial LER for claudication is associated with a low overall rate of major amputation. However, performing multiple reinterventions for claudication is associated with progression to CLTI.

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