Despite the fact that asthma is a widespread disease across the world, its etiology is still unknown. The interplay of epigenetics, DNA damage, and environmental allergens in the development of asthma is becoming increasingly clear. The role of epigenetics and DNA damage in asthma will be the focus of this review. Environmental allergens, notably home dust mites, have been shown to cause oxidative DNA damage in airway epithelial cells, according to accumulating data. Repairing this DNA damage has been linked to Th2 cytokine production and the development of allergic inflammation.

Studies on the involvement of epigenetics, DNA damage, and environmental allergens in the development of asthma have begun to uncover their intricate interconnections and functions in the development of asthma. Further research in these areas might lead to innovative preventive and treatment methods.

Reference: https://journals.lww.com/co-allergy/Abstract/2018/02000/Role_of_epigenetics_and_DNA_damage_in_asthma.6.aspx