The most prevalent endocrinopathy affecting women of reproductive age is polycystic ovarian syndrome (PCOS). The purpose of this study was to assess the impact of lifestyle changes and synbiotic supplementation on PCOS. A randomised (1:1), double-blind, placebo-controlled study was conducted. The Rotterdam criteria were used to identify overweight and obese women with PCOS. Evaluations were conducted at the start of treatment and again three months afterwards. A 5% reduction in BMI was accompanied by substantial reductions in waist, hip, and thigh circumferences in the placebo group. The synbiotic group’s BMI decreased by 8%, which was substantially larger than the control group and was accompanied by decreases in waist, hip, and thigh circumferences. Testosterone did not decrease much in the placebo group, but it did fall by 32% in the synbiotic group. The testosterone drop in the synbiotic group was substantially higher than in the placebo group.
Synbiotic supplementation enhanced the impact of lifestyle changes on weight loss and resulted in a substantial decrease in serum testosterone.
Reference; https://academic.oup.com/jcem/article/106/9/2566/6288476
