The study aims at understanding the roles of SAD (small artery diseases) and MAC (medial arterial calcification) in subjects with CLTI (chronic limb-threatening ischemia). The study also aims at understanding the correlation between PAD (peripheral artery disease) or outcomes and these factors.

The researchers conducted a retrospective study with 259 limbs among 223 subjects. The subjects taken for the study were those who underwent angiographic foot vessel study or foot radiography at least six months after the intervention. The study also classified the subjects into three groups based on MAC and SAD (0-absent, -moderate, and 2-severe).

Group 0 has 55 limbs, 89 in group 1 and 115 in group 2. The SAD score put 67 in group 0, 76 in group 1, and 116 in group 2. The specificity and sensitivity of the MAC score in screening SAD (group 0 and 2) was 98.1% and 100%. The parameters for group 1 were 92.7% and 99.1%. The SAD and MAC scores help to understand the clinical endpoints. MAC score showed as a risk factor for any adverse limb event.

SAD and MAC are important factors in understanding the progression of CLTI patients’ outcomes. They are also important elements in indicating any adverse major limb events in patients with CLTI.