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Role of Wnt5a in the Pathogenesis of Inflammatory Diseases.

Role of Wnt5a in the Pathogenesis of Inflammatory Diseases.
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Pashirzad M, Shafiee M, Rahmani F, Behnam-Rassouli R, Hoseinkhani F, Ryzhikov M, Moradi Binabaj M, Parizadeh MR, Avan A, Hassanian SM,


Pashirzad M, Shafiee M, Rahmani F, Behnam-Rassouli R, Hoseinkhani F, Ryzhikov M, Moradi Binabaj M, Parizadeh MR, Avan A, Hassanian SM, (click to view)

Pashirzad M, Shafiee M, Rahmani F, Behnam-Rassouli R, Hoseinkhani F, Ryzhikov M, Moradi Binabaj M, Parizadeh MR, Avan A, Hassanian SM,

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Journal of cellular physiology 2017 02 16232(7) 1611-1616 doi 10.1002/jcp.25687
Abstract

Wnt5a initiates pro-inflammatory responses through activation of non-canonical Wnt signaling pathway. Pro-inflammatory functions of Wnt5a trigger pro-inflammatory signaling cascades and increase secretion of pro-inflammatory cytokines and chemokines. Wnt5a as a potent signaling molecule is strongly implicated in a number of diseases including cancer, diabetes, metabolic disorders, and of special interest in this review, inflammatory diseases. This review summarizes the role of Wnt5a in the pathogenesis of inflammatory diseases including atherosclerosis, rheumatoid arthritis, psoriasis vulgaris and sepsis, promoting greater understanding, and clinical management of these diseases. J. Cell. Physiol. 232: 1611-1616, 2017. © 2016 Wiley Periodicals, Inc.

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