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Salicylic acid derivatives and phenylspirodrimanes from the sponge-associated fungus Hansfordia sinuosae.

Salicylic acid derivatives and phenylspirodrimanes from the sponge-associated fungus Hansfordia sinuosae.
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Wu ZH, Li Y, Li Y, Ma M, Chen JL,


Wu ZH, Li Y, Li Y, Ma M, Chen JL, (click to view)

Wu ZH, Li Y, Li Y, Ma M, Chen JL,

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Journal of Asian natural products research 2017 08 23() 1-7 doi 10.1080/10286020.2017.1367924

Abstract

Three new salicylic acid derivatives (1-3) and a known one, 6-(3′-hydroxypropyl)-2-hydroxybenzoic acid (4), together with seven known phenylspirodrimanes (5-11), were isolated from the sponge-associated fungus Hansfordia sinuosae, collected from the South China Sea. HRESIMS, FT-IR Spectroscopy, and NMR techniques including COSY, HSQC, and HMBC were used to elucidate the structures of these compounds. The inhibitory effects of the isolated compounds (1-11) against HIV-1 virus were evaluated, and most of the phenylspirodrimanes (5, 8-11) showed varying degrees of anti-HIV activity.

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