For a study, researchers sought to assess the standard of papers describing sepsis health care expenses and to give a global picture of hospital-related costs for sepsis in adult patients. To find pertinent studies between January 2010 and January 2022, investigators thoroughly searched PubMed, EMBASE, Cochrane, and Google Scholar. They chose articles that defined sepsis, offered cost and cost-effectiveness assessments, and explained how they calculated their costs. All costs have been converted to US dollars for 2020. Medians and interquartile ranges (IQRs) were calculated for different sepsis expenses. The Drummond 10-item checklist was used to rate the caliber of economic studies. About 26 studies in total satisfied the eligibility requirements. Between €1,101 to €91,951, the mean total hospital costs per patient were very variable. The median (IQR) yearly costs per nation for sepsis were €36,191 (€17,158 – €53,349), or €50 (€34 – €84) per capita. Around 2.65% of the healthcare budget was allocated to sepsis, equivalent to 0.33% of the gross national product (GNP). While sepsis costs were generally expensive, there was a great deal of variation between nations. Additional research into the effects of sepsis costs, particularly in the general ward, could aid in the justification, design, and monitoring of programs for the early detection, diagnosis, and treatment of this potentially curable and time-sensitive condition.