Here are what the editors at HealthDay consider to be the most important developments in Pathology for September 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

CDC Says People Can Contract Tuberculosis From Deer

MONDAY, Sept. 30, 2019 (HealthDay News) — According to the U.S. Centers for Disease Control and Prevention, humans can contract a rare type of tuberculosis, called bovine tuberculosis, from deer.

CNN Article
More Information: CDC

Crude Incidence of Candidemia 8.7 Per 100,000 in 2012 to 2016

MONDAY, Sept. 30, 2019 (HealthDay News) — The crude incidence of candidemia was 8.7 per 100,000 population across four states in 2012 to 2016, according to a surveillance summary published in the Sept. 27 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Low Cancer Suspicion Tied to Delay in CRC Referral in Primary Care

MONDAY, Sept. 30, 2019 (HealthDay News) — Delay in referral for colorectal cancer (CRC) in primary care is associated with low cancer suspicion, according to a study published in the September/October issue of Annals of Family Medicine.

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Infectious Disease Consultation May Lower Candida Mortality

FRIDAY, Sept. 27, 2019 (HealthDay News) — Mortality is lower for patients with candida bloodstream infection receiving an infectious disease consultation, according to a study published online Sept. 24 in The Lancet Infectious Diseases.

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Recommendations Developed for Evaluating Chronic Diarrhea

FRIDAY, Sept. 27, 2019 (HealthDay News) — In new American Gastroenterological Association (AGA) clinical practice guidelines, published in the September issue of Gastroenterology, recommendations are presented for laboratory evaluation of chronic watery diarrhea.

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Average Annual Premium for Workers Increased in 2019

THURSDAY, Sept. 26, 2019 (HealthDay News) — In 2019, the average annual health insurance premium for workers increased slightly for single coverage and family coverage, according to a report published online Sept. 25 in Health Affairs.

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Serum IL-35 Levels Tied to Bone Loss With Rheumatoid Arthritis

THURSDAY, Sept. 26, 2019 (HealthDay News) — Serum interleukin (IL)-35 levels are associated with bone loss and may represent a novel therapeutic target for postmenopausal women with rheumatoid arthritis (RA), according to a study published online Aug. 26 in Mediators of Inflammation.

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Blast Count Prognostic for CML Presenting in Advanced Phase

THURSDAY, Sept. 26, 2019 (HealthDay News) — Blast count seems to be the main prognostic count for patients with chronic myeloid leukemia (CML) presenting in an advanced phase, according to a study published online Aug. 27 in the American Journal of Hematology.

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Racial/Ethnic Disparities in Mortality Persist in the U.S.

WEDNESDAY, Sept. 25, 2019 (HealthDay News) — There are still racial and ethnic disparities in mortality, and these disparities are widening for some age groups, according to a study published online Sept. 24 in the American Journal of Preventive Medicine.

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Incidence of Hodgkin Lymphoma Up in Least Deprived Areas

WEDNESDAY, Sept. 25, 2019 (HealthDay News) — Individuals living in the most affluent areas of the United Kingdom seem to have an increased incidence of Hodgkin lymphoma (HL), according to a study published in the August issue of BMJ Open.

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Exposure to Insecticide Might Explain ‘Sonic Attack’ in Cuba

TUESDAY, Sept. 24, 2019 (HealthDay News) — In 2016, American and Canadian diplomats in Cuba complained of vertigo, ringing in the ears, pain, blurred vision, dizziness, and memory and concentration problems.

CNN Article

USPSTF Urges Asymptomatic Bacteriuria Screening in Pregnancy

TUESDAY, Sept. 24, 2019 (HealthDay News) — The U.S. Preventive Services Task Force (USPSTF) recommends using a urine culture to screen pregnant persons for asymptomatic bacteriuria (Grade B recommendation) but does not recommend screening nonpregnant adults. These findings form the basis of a final recommendation statement published in the Sept. 24 issue of the Journal of the American Medical Association.

Evidence Report
Final Recommendation Statement
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Protected Health Info Breaches Compromise Sensitive Data

MONDAY, Sept. 23, 2019 (HealthDay News) — Most protected health information (PHI) breaches compromise sensitive demographic and/or financial information, according to a research letter published online Sept. 23 in the Annals of Internal Medicine.

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Higher Mortality Seen for Male Breast Cancer Patients

MONDAY, Sept. 23, 2019 (HealthDay News) — Male breast cancer patients have higher mortality after cancer diagnosis than female patients, according to a study published online Sept. 19 in JAMA Oncology.

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Medical Students Not Ready to Provide Nutritional Care

THURSDAY, Sept. 19, 2019 (HealthDay News) — Medical education does not equip students to provide high-quality, effective nutrition care, according to a review published in the September issue of The Lancet Planetary Health.

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Skipping Cancer Referral Appointments Linked to Earlier Death

THURSDAY, Sept. 19, 2019 (HealthDay News) — Cancer diagnosis is less likely in patients not attending referral appointments for suspected cancer, but these patients have worse early mortality outcomes than attending patients, according to a study published online Sept. 11 in Cancer Epidemiology.

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Electronic Nose Analysis May Predict Response to Anti-PD-1 Therapy in NSCLC

WEDNESDAY, Sept. 18, 2019 (HealthDay News) — For patients with non-small cell lung cancer (NSCLC), responders and nonresponders can be differentiated by a metal oxide semiconductor electronic nose (eNose) analysis of exhaled breath before starting antiprogrammed death ligand 1 (anti-PD-1) therapy, according to a study published online Sept. 17 in the Annals of Oncology.

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Initiating Empirical Tx for Sepsis Reduces Blood Culture Sensitivity

TUESDAY, Sept. 17, 2019 (HealthDay News) — When empirical antimicrobial therapy is initiated in patients with severe manifestations of sepsis, the sensitivity of blood cultures drawn shortly after treatment initiation is reduced, according to a study published online Sept. 17 in the Annals of Internal Medicine.

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Brain Changes Differ for β-Amyloid, Cerebrovascular Burden

FRIDAY, Sept. 13, 2019 (HealthDay News) — β-amyloid (Aβ) and cerebrovascular disease burden have divergent effects on longitudinal default mode network and executive control network functional connectivity (FC) changes in amnestic mild cognitive impairment (MCI) and subcortical vascular MCI, according to a study published online Sept. 11 in Neurology.

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Scientists Use Gene-Editing Tool CRISPR in Attempt to Cure HIV

THURSDAY, Sept. 12, 2019 (HealthDay News) — The first attempt to use the gene-editing tool CRISPR to cure HIV infection was unsuccessful, but the approach does show promise.

AP News Article
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HIV Infection May Raise Risk for Atrial Fibrillation

THURSDAY, Sept. 12, 2019 (HealthDay News) — HIV infection is independently associated with an increased risk for atrial fibrillation (AF), according to a research letter published in the Sept. 17 issue of the Journal of the American College of Cardiology.

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EPA to Phase Out Chemical Testing on Mammals

WEDNESDAY, Sept. 11, 2019 (HealthDay News) — The eventual elimination of chemical testing on mammals was announced Tuesday by the U.S. Environmental Protection Agency.

The New York Times Article
More Information: EPA

New Strain of S. pyogenes Causing Scarlet Fever in U.K.

WEDNESDAY, Sept. 11, 2019 (HealthDay News) — A new strain of Streptococcus pyogenes is causing scarlet fever, according to a study published online Sept. 10 in The Lancet Infectious Diseases.

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Guideline Updated for Screening, Surveillance of Barrett Esophagus

WEDNESDAY, Sept. 11, 2019 (HealthDay News) — In a guideline published in the September issue of Gastrointestinal Endoscopy, updated recommendations are presented for screening and surveillance among patients with Barrett esophagus (BE).

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Serum Biomarker Linked to Brain Atrophy in Multiple Sclerosis

WEDNESDAY, Sept. 11, 2019 (HealthDay News) — Serum neurofilament light chain (sNFL) levels are significantly associated with clinical and neuroimaging outcomes in multiple sclerosis (MS), according to a study published online Aug. 12 in JAMA Neurology.

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Poverty Rate Drops, but Fewer Americans Have Health Insurance

TUESDAY, Sept. 10, 2019 (HealthDay News) — The percentage of Americans living in poverty declined in 2018, but the rate of those without health insurance increased, according to a U.S. Census Bureau report.

The New York Times Article
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Herd Protection Against Oral HPV Infections Seen Among Men

TUESDAY, Sept. 10, 2019 (HealthDay News) — In unvaccinated men aged 18 to 59 years, the prevalence of vaccine-type oral human papillomavirus (HPV) decreased between 2009 to 2010 and 2015 to 2016, according to a research letter published in the Sept. 10 issue of the Journal of the American Medical Association.

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Quality-Improvement Tool Improves Iron Outcomes in Pregnancy

TUESDAY, Sept. 10, 2019 (HealthDay News) — A standardized iron deficiency (ID) toolkit increases detection and management of anemia during pregnancy, according to a study published Aug. 20 in PLOS Medicine.

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Gout May Up Risk for Progression of Chronic Kidney Disease

MONDAY, Sept. 9, 2019 (HealthDay News) — Gout is associated with an elevated risk for chronic kidney disease (CKD) progression, according to a study published online Aug. 28 in BMJ Open.

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Racial, Ethnic Underrepresentation Found in Med School Matriculants

FRIDAY, Sept. 6, 2019 (HealthDay News) — Among medical school matriculants, black, Hispanic, and American Indian or Alaska Native (AIAN) students are underrepresented, according to a study published online Sept. 4 in JAMA Network Open.

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Machine Learning Algorithms Promising in Kidney Diagnostics

FRIDAY, Sept. 6, 2019 (HealthDay News) — Machine learning algorithms could aid with classification of kidney biopsy samples, according to two studies published online Sept. 5 in the Journal of the American Society of Nephrology.

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ATS Guideline Outlines Lab Tests for Diagnosis of Fungal Infections

FRIDAY, Sept. 6, 2019 (HealthDay News) — Rapid and accurate diagnosis of fungal infections relies on appropriate use of diagnostic testing, according to the official American Thoracic Society clinical practice guideline published in the Sept. 1 issue of the American Journal of Respiratory and Critical Care Medicine.

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Psychedelic Research Center Created at Johns Hopkins University

THURSDAY, Sept. 5, 2019 (HealthDay News) — A research center that will assess the use of psychedelic drugs to treat conditions such as addiction, alcoholism, and depression was announced by Johns Hopkins University.

ABC News Article

Majority of U.S. Doctors Believe ACA Has Improved Access to Care

THURSDAY, Sept. 5, 2019 (HealthDay News) — Sixty percent of U.S. physicians believe that the Affordable Care Act (ACA) has improved access to care and insurance after five years of implementation, according to a report published in the September issue of Health Affairs.

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Algorithm Based on Response, Biology Guides Neuroblastoma Tx

THURSDAY, Sept. 5, 2019 (HealthDay News) — Use of a response- and biology-based treatment algorithm for intermediate-risk neuroblastoma is associated with excellent survival and reduces treatment for some patients, according to a study published online Aug. 6 in the Journal of Clinical Oncology.

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Postictal Serotonin Levels Associated With Periictal Apnea

WEDNESDAY, Sept. 4, 2019 (HealthDay News) — Seizure-related increases in serum serotonin (5-HT) levels are associated with a reduced incidence of seizure-related breathing dysfunction, according to a study published online Sept. 4 in Neurology.

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Marriage Associated With Lower Dementia Risk

TUESDAY, Sept. 3, 2019 (HealthDay News) — People who remain married in older age may have a lower dementia risk, according to a study recently published in The Journals of Gerontology: Series B.

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Microplastics Detected in Human Stool Samples

TUESDAY, Sept. 3, 2019 (HealthDay News) — Microplastics have been detected in stool samples of healthy volunteers, according to research published online Sept. 3 in the Annals of Internal Medicine.

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